TrenA (Trenbolone Acetate) is an injectable non-estrogenic steroid derived from nandrolone.

Trenbolone is highly favored by athlete for its ability to increase muscle hardness, definition, and raw strength, without unwanted water retention and fat mass gains.

Estrogenic Side Effects

TrenA (Trenbolone Acetate) is not aromatized by the body, and is not measurably estrogenic. This steroid displays significant binding affinity for the progesterone receptor. The side effects associated with progesterone including negative feedback inhibition of testosterone production, body fat gain and gynecomastia can occur.

The use of an anti-estrogen is often sufficient to mitigate gynecomastia caused by progestational anabolic/androgenic steroids.

Androgenic Side Effects

Although classified as an anabolic steroid, androgenic side effects are still common with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth.

Anabolic/androgenic steroids may also aggravate male pattern hair loss.

Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement.

Hepatotoxicity Side Effects

TrenA (Trenbolone Acetate) does not have hepatotoxic effects and therefore, liver toxicity is unlikely. Although unlikely, hepatotoxicity cannot be completely excluded, especially with high doses.

Cardiovascular Side Effects

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis.

The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism.

Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular strain, it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active steroid administration. Supplementing with fish oils and a natural cholesterol/antioxidant formula is also recommended.

Testosterone Suppression

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production.

Testosterone-based drugs will, likewise, have a strong effect on the hypothalamic regulation of natural steroid hormones. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession.

Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Administration for Men

It is most commonly used at a dosage of 100 – 300 mg per week. Due to the short-acting nature of acetate esters the total week’s dosage is to be be further divided to reduce the volume of each injection administering the drug two to three times per week. One should also take caution to rotate injection sites regularly, so as to avoid irritation or infection.

The positive effects of this drug become most apparent when it is used for longer cycles, usually lasting 8 weeks or more in duration.

TrenA (Trenbolone Acetate) is a very versatile drug, and can be combined with a number of other agents depending on the desired result.

Administration for Women

TrenA (Trenbolone Acetate) is rarely used with women in clinical medicine.

TrenA (Trenbolone Acetate) is not recommended for women for performance enhancing purposes due to its strong androgenic nature and tendency to produce virilizing side effects.